As COVID-19 restrictions have eased, the resumption of international travel and sexual interactions at large gatherings have fueled the continued spread of human mpox beyond its endemic regions.1–3 The current global circulation of the clade II variant of the monkeypox virus (MPXV) has been marked by unique person-to-person transmission, including sexual and non-sexual contact.1,3,4 The current transmission dynamics of MPXV indicate changes in the virus’s biological characteristics, human behavior, and clinical presentations, making surveillance particularly challenging in resource-limited countries.